Seroprevalence of Sickle Cell Anemia And Thalassemia in Suspected Case of Genetic Disorders in Tribal Predominant Population, Ranchi ,India

Introduction: The Hemoglobinopathies are one of the major public health problems in tribal predominant population. Objective: To estimate the seroprevalence of Sickle Cell Anemia and Thalassemia in suspected cases of genetic disorders by using HPLC retention time chromatogram method in tribal predominant population, Ranchi, Jharkhand. Methods: All Blood sample of suspected cases of genetic disorders were assessed in the department of Laboratory Medicine, Rajendra Institute of Medical Sciences, Ranchi, India for work up of anemia or other blood related disorders in year 2013. This blood samples were assessed on BIORAD variant II. Results: A total of 107 blood samples were examined by HPLC retention time chromatogram . Out of these, 63(58.88%) cases showed abnormal hemoglobin fractions. The major abnormality observed was of high HbA2 . A cutoff value of >3.9% was considered for diagnosis of beta thalassemia trait (BTT). A total of 13 cases (12.1%) of BTT were diagnosed. Other hemoglobinopathies were as follows: Sickle homo 12 (11.2%), Sickle trait 10 (9.3%), dB Thal trait 9 (8.4%), Sickle Thal 7 (6.5%), Heredetery Persistent Fetal Hemoglobin (HPFH) 7 (6.5%), B Thal Major 5 (4.6%). Conclusion: This study revealed that seroprevalence of Sickle Cell Anemia and Thalassemia is 58.88% in study sample.